DexPak Jr and Sodium Diuril
Determining the interaction of DexPak Jr and Sodium Diuril and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using dexamethasone, tell your doctor if you also use chlorothiazide. You may need a dose adjustment or special tests in order to safely take both medications together. This combination may cause muscle pains or cramps, loss of appetite, weakness, dizziness, or confusion. If you take both medications together, tell your doctor if you have any of these symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant use of corticosteroids and agents that deplete potassium (e.g., potassium-wasting diuretics, amphotericin B, cation exchange resins) may result in increased risk of hypokalemia. Corticosteroids can produce hypokalemia and other electrolyte disturbances via mineralocorticoid effects, the degree of which varies with the agent (from most to least potent: fludrocortisone - cortisone/hydrocortisone - prednisolone/prednisone - other glucocorticoids) and route of administration (i.e. systemic vs. local). However, large systemic doses of any corticosteroid can demonstrate these effects, particularly if given for longer than brief periods. When used pharmacologically, adrenocorticotropic agents such as corticotropin have similar mineralocorticoid activities as cortisone and hydrocortisone.
MANAGEMENT: Patients receiving potassium-depleting agents with corticosteroids should be monitored closely for development of hypokalemia, particularly if fludrocortisone or large doses of another corticosteroid or adrenocorticotropic agent is given. Potassium supplementation may be necessary. Patients should be advised to notify their physician if they experience signs of electrolyte disturbances such as weakness, lethargy, and muscle pains or cramps.
- Morris GC, Egan JG, Jones MK "Hypokalaemic paralysis induced by bolus prednisolone in Graves' disease." Aust N Z J Med 22 (1992): 312
- Thomas TP "The complications of systemic corticosteroid therapy in the elderly." Gerontology 30 (1984): 60-5
- "Product Information. Hydeltrasol (prednisolone)." Merck & Co, Inc, West Point, PA.
- Ramsahoye BH, Davies SV, el-Gaylani N, Sandeman D, Scanlon MF "The mineralocorticoid effects of high dose hydrocortisone." BMJ 310 (1995): 656-7
- Powell JR "Steroid and hypokalemic myopathy after corticosteroids for ulcerative colitis. Systemic and tropical application." Am J Gastroenterol 52 (1969): 425-32
- Thorn GW "Clinical considerations in the use of corticosteroids." N Engl J Med 274 (1966): 775-81
- Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
- Chrousos GA, Kattah JC, Beck RW, Cleary PA "Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial." JAMA 269 (1993): 2110-2
Generic Name: dexamethasone
Brand name: Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: DexPak 10 Day Taperpak, DexPak 10 Day TaperPak
Generic Name: chlorothiazide
Brand name: Diuril, Diuril Sodium
Synonyms: Diuril Sodium (Intravenous)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- DexPak Jr-Sodium Edecrin
- DexPak Jr-Sodium Ferric Gluconate
- DexPak Jr-Sodium ferric gluconate complex
- DexPak Jr-Sodium ferric gluconate complex Intravenous
- DexPak Jr-Sodium Glycerophosphate Pentahydrate
- DexPak Jr-Sodium hyaluronate injection
- Sodium Diuril-Dexrazoxane
- Sodium Diuril-Dexrazoxane Hydrochloride
- Sodium Diuril-Dexrazoxane Intravenous
- Sodium Diuril-Dextenza Insert
- Sodium Diuril-Dextenza intraocular
- Sodium Diuril-Dextran 40