Dexrazoxane Hydrochloride and Estradiol Vaginal Insert

• Generic Name: dexrazoxane
• Dosage Forms: n.a.
• Other Brand Names: Totect, Zinecard

Reduction of the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of ≥300 mg/m2 and would benefit from continued doxorubicin therapy (designated an orphan drug by FDA for this use).

Not recommended for use with initiation of doxorubicin therapy. (See Effectiveness of Cytotoxic Regimens under Cautions.)

• Generic Name: estradiol topical
• Dosage Forms: n.a.
• Other Brand Names: Estrace Vaginal, Estring, Vagifem, Yuvafem, Imvexxy

• It is used to treat vaginal pain during sex caused by changes that happen with menopause.
• It may be given to you for other reasons. Talk with the doctor.