Dexrazoxane Hydrochloride and Lofexidine

• Generic Name: dexrazoxane
• Dosage Forms: n.a.
• Other Brand Names: Totect, Zinecard

Reduction of the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of ≥300 mg/m2 and would benefit from continued doxorubicin therapy (designated an orphan drug by FDA for this use).

Not recommended for use with initiation of doxorubicin therapy. (See Effectiveness of Cytotoxic Regimens under Cautions.)

• Generic Name: lofexidine
• Dosage Forms: n.a.
• Other Brand Names: Lucemyra

Lofexidine works by blocking the release of norepinephrine, a hormone similar to adrenaline that contributes to opioid withdrawal symptoms.

Lofexidine is used to reduce opioid withdrawal symptoms after you stop taking an opioid suddenly.

Lofexidine will not treat opioid addiction.

Lofexidine may also be used for purposes not listed in this medication guide.