Dexrazoxane Intravenous and Saxagliptin Hydrochloride

• Generic Name: dexrazoxane
• Dosage Forms: n.a.
• Other Brand Names: Totect, Zinecard

Dexrazoxane is used to help prevent or lessen the toxic effects of certain cancer medicines used to treat women with breast cancer.

Dexrazoxane injection is used to treat tissue damage caused by the leakage of certain cancer medicines from the injection site.

Dexrazoxane is to be given only by or under the direct supervision of your doctor.

• Generic Name: saxagliptin
• Dosage Forms: n.a.
• Other Brand Names: Onglyza

Used as monotherapy as an adjunct to diet and exercise for management of type 2 diabetes mellitus in patients whose hyperglycemia cannot be controlled by diet and exercise alone.

Used in combination with metformin (separately or as fixed combination of saxagliptin and extended-release metformin), a sulfonylurea, a thiazolidinedione (e.g., a peroxisome proliferator-activated receptor-γ [PPAR-γ] agonist) or insulin for management of type 2 diabetes mellitus in patients who do not achieve adequate glycemic control with diet, exercise, and metformin, sulfonylurea, thiazolidinedione monotherapy, and/or insulin. Patients initially receiving an oral antidiabetic agent will eventually require multiple oral antidiabetic agents of different therapeutic classes and/or insulin for adequate glycemic control because of declining β2-cell function with disease progression.

The fixed combination of saxagliptin and dapagliflozin is used as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) suggests a DPP-4 inhibitor as one of several alternatives for initial monotherapy in patients with metformin contraindications (e.g., renal disease, hepatic disease, GI intolerance, risk of lactic acidosis). DPP-4 inhibitors also recommended as part of combination therapy, particularly with both postprandial and fasting plasma glucose elevations.

Not indicated for type 1 diabetes mellitus or diabetic ketoacidosis; insulin is required in these conditions.