Dextran 40 and Lefamulin Acetate

• Generic Name: dextran, low molecular weight
• Dosage Forms: n.a.
• Other Brand Names: LMD

Early fluid replacement and plasma volume expansion in the adjunctive treatment of certain types of shock or impending shock (e.g., burns, surgery, hemorrhage, or other trauma in which a circulating volume deficit is present) when whole blood or blood products are not available, or when the need for haste precludes the necessary cross-matching of blood.

Minimizes sludging of blood as a result of microcirculation effects.

Not a replacement for other forms of therapy; complementary to fluids and electrolytes.

Priming fluid (alone or as an additive to other priming fluids) in pump oxygenators for perfusion during extracorporeal circulation.

Prophylaxis of venous thrombosis and pulmonary embolism for surgical procedures associated with a high risk of thromboembolic complications (e.g., hip surgery).

May be beneficial in patients undergoing hip surgery; however, has not been shown to be more effective than oral anticoagulants or heparin in patients undergoing general surgery.

The American College of Chest Physicians (ACCP) does not recommend as sole method of thromboprophylaxis in elective hip arthroplasty.

• Generic Name: lefamulin
• Dosage Forms: n.a.
• Other Brand Names: Xenleta

Lefamulin acetate is a pleuromutilin antibacterial indicated in adults for the treatment of community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

To reduce the development of drug resistant bacteria and maintain the effectiveness of lefamulin acetate and other antibacterial drugs, lefamulin acetate should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.