Dextroamphetamine and Amphetamine Extended-Release Capsules (Adderall XR) and Esomeprazole injection
Determining the interaction of Dextroamphetamine and Amphetamine Extended-Release Capsules (Adderall XR) and Esomeprazole injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using amphetamine together with esomeprazole. Combining these medications may affect the onset of effects of amphetamine. Contact your doctor if your condition worsens or you experience increased side effects. Your doctor may be able to prescribe alternative treatments that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of proton pump inhibitors with extended release forms of amphetamine may affect the release rate of amphetamine from the capsule. The mechanism is reduction of gastric acidity. When omeprazole 40 mg/day was concomitantly administered with a mixed salts amphetamine 20 mg, the median Tmax decreased by 1.25 hours for d-amphetamine and by 2.5 hours for l-amphetamine. The systemic exposure (AUC) and maximum plasma concentration (Cmax) were unchanged.
MANAGEMENT: Patients should be monitored for changes in clinical effects during concomitant use.
- "Product Information. Adderall XR (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc, Florence, KY.
Generic Name: amphetamine / dextroamphetamine
Brand name: Adderall, Adderall XR, Mydayis
Synonyms: Amphetamine and dextroamphetamine, Dextroamphetamine and Amphetamine
Generic Name: esomeprazole
Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV
Synonyms: Esomeprazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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