Dextromethorphan Hydrobromide and Quinidine Sulfate and Entyvio

• Generic Name: dextromethorphan / quinidine
• Dosage Forms: n.a.
• Other Brand Names: Nuedexta

The fixed combination of dextromethorphan hydrobromide and quinidine sulfate (dextromethorphan/quinidine; Nuedexta) is used in the treatment of PBA.

PBA occurs secondary to various otherwise unrelated neurologic conditions (e.g., amyotrophic lateral sclerosis [ALS], multiple sclerosis [MS], dementia of the Alzheimer's type [Alzheimer's disease] or other dementia, parkinsonian syndrome, stroke, traumatic brain injury) and is characterized by involuntary, sudden, uncontrollable, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to the underlying emotional state.

Studies supporting efficacy in PBA were conducted in patients with underlying ALS or MS.

Safety and efficacy in the treatment of other common types of emotional lability (e.g., those occurring in patients with Alzheimer's disease and other dementias) not established.

• Generic Name: vedolizumab
• Dosage Forms: n.a.
• Other Brand Names: Entyvio

Entyvio (vedolizumab) reduces the effects of a substance in the body that can cause inflammation.

Entyvio is used in adults with moderate to severe ulcerative colitis (UC), or moderate to severe Crohn's disease.

Entyvio treats active disease and may help keep UC or Crohn's symptoms under control long term. Vedolizumab may also reduce the need for steroid medicines in helping to control symptoms long term.

Entyvio is usually given after other medicines have been tried without success.