Dextromethorphan Hydrobromide and Quinidine Sulfate and Plazomicin

• Generic Name: dextromethorphan / quinidine
• Dosage Forms: n.a.
• Other Brand Names: Nuedexta

The fixed combination of dextromethorphan hydrobromide and quinidine sulfate (dextromethorphan/quinidine; Nuedexta) is used in the treatment of PBA.

PBA occurs secondary to various otherwise unrelated neurologic conditions (e.g., amyotrophic lateral sclerosis [ALS], multiple sclerosis [MS], dementia of the Alzheimer's type [Alzheimer's disease] or other dementia, parkinsonian syndrome, stroke, traumatic brain injury) and is characterized by involuntary, sudden, uncontrollable, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to the underlying emotional state.

Studies supporting efficacy in PBA were conducted in patients with underlying ALS or MS.

Safety and efficacy in the treatment of other common types of emotional lability (e.g., those occurring in patients with Alzheimer's disease and other dementias) not established.

• Generic Name: plazomicin
• Dosage Forms: n.a.
• Other Brand Names: Zemdri

Plazomicin is an antibiotic medicine used to treat serious infections of the bladder or kidneys.

plazomicin can cause serious or disabling side effects that may not be reversible. Plazomicin should be used only for infections that cannot be treated with a safer antibiotic.

Plazomicin may also be used for purposes not listed in this medication guide.