Dextromethorphan Hydrobromide and Quinidine Sulfate and Ticarcillin and clavulanate Intravenous

• Generic Name: dextromethorphan / quinidine
• Dosage Forms: n.a.
• Other Brand Names: Nuedexta

The fixed combination of dextromethorphan hydrobromide and quinidine sulfate (dextromethorphan/quinidine; Nuedexta) is used in the treatment of PBA.

PBA occurs secondary to various otherwise unrelated neurologic conditions (e.g., amyotrophic lateral sclerosis [ALS], multiple sclerosis [MS], dementia of the Alzheimer's type [Alzheimer's disease] or other dementia, parkinsonian syndrome, stroke, traumatic brain injury) and is characterized by involuntary, sudden, uncontrollable, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to the underlying emotional state.

Studies supporting efficacy in PBA were conducted in patients with underlying ALS or MS.

Safety and efficacy in the treatment of other common types of emotional lability (e.g., those occurring in patients with Alzheimer's disease and other dementias) not established.

• Generic Name: clavulanate / ticarcillin
• Dosage Forms: n.a.
• Other Brand Names: Timentin

Ticarcillin and clavulanate combination is used to treat bacterial infections in many different parts of the body.

Ticarcillin and clavulanate combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria or preventing their growth. However, ticarcillin and clavulanate will not work for colds, flu, or other virus infections.

Ticarcillin and clavulanate was to be given only by or under the direct supervision of a doctor.

The ticarcillin/clavulanate combination was withdrawn from the United States market on February 9, 2015.