Dextromethorphan Hydrobromide and Quinidine Sulfate and Zymine-D

• Generic Name: dextromethorphan / quinidine
• Dosage Forms: n.a.
• Other Brand Names: Nuedexta

The fixed combination of dextromethorphan hydrobromide and quinidine sulfate (dextromethorphan/quinidine; Nuedexta) is used in the treatment of PBA.

PBA occurs secondary to various otherwise unrelated neurologic conditions (e.g., amyotrophic lateral sclerosis [ALS], multiple sclerosis [MS], dementia of the Alzheimer's type [Alzheimer's disease] or other dementia, parkinsonian syndrome, stroke, traumatic brain injury) and is characterized by involuntary, sudden, uncontrollable, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to the underlying emotional state.

Studies supporting efficacy in PBA were conducted in patients with underlying ALS or MS.

Safety and efficacy in the treatment of other common types of emotional lability (e.g., those occurring in patients with Alzheimer's disease and other dementias) not established.

• Generic Name: pseudoephedrine / triprolidine
• Dosage Forms: n.a.
• Other Brand Names: A-Phedrin, Allerfrim, Allerphed, Altafed, Aphedrid, Aprodine, Biofed-PE, Genac, Hist-PSE, Histafed, Pediatex TD, Trip-PSE, Vi-Sudo, Zymine-D, Actifed, Allercon, Triafed, Triposed, Triofed, Actedril, Atridine, Atrofed, Atrogen, Hista-Tabs, LA Nasal Decongestant, Ridifed, Tri-Sudo, Triphed, Triptifed, Actagen, Allerfrin, Triacin, Ritifed, Actacin, Triacting, Trisofed, Pseudocot-T, Sudafed Sinus Nighttime, Zymine DXR, Tripohist D, Wal-Act

Triprolidine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of pseudoephedrine and triprolidine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Zymine-D may also be used for purposes not listed in this medication guide.