Dextrose and Telotristat Etiprate

• Generic Name: glucose
• Dosage Forms: n.a.
• Other Brand Names: Dextrose, BD Glucose, Dex4, Insta-Glucose, Relion Grape, TRUEplus, Trutol Fruit Punch, Rematex, Ziks Arthritis Pain Relief

Dextrose (glucose) is a form of natural sugar that is normally produced by the liver. Glucose is a source of energy, and all the cells and organs in your body need glucose to function properly. Glucose as a medication is given either by mouth (orally) or by injection.

Dextrose is used to treat very low blood sugar (hypoglycemia), most often in people with diabetes mellitus. Dextrose is given by injection to treat insulin shock (low blood sugar caused by using insulin and then not eating a meal or eating enough food afterward). This medicine works by quickly increasing the amount of glucose in your blood.

Dextrose is also used to provide carbohydrate calories to a person who cannot eat because of illness, trauma, or other medical condition. It is sometimes given to people who are sick from drinking too much alcohol.

Dextrose may also be used to treat hyperkalemia (high levels of potassium in your blood).

• Generic Name: telotristat
• Dosage Forms: n.a.
• Other Brand Names: Xermelo

Used (in combination with somatostatin analog therapy) for treatment of carcinoid syndrome diarrhea inadequately controlled by somatostatin analog therapy alone (designated an orphan drug by FDA for the treatment of carcinoid syndrome in patients with neuroendocrine tumors).

Carcinoid syndrome, a condition associated with serotonin overproduction, is characterized by flushing, diarrhea, wheezing, occasionally congestive heart failure, and various other manifestations. Although somatostatin analogs (e.g., octreotide, lanreotide) are standard treatment for carcinoid syndrome and are effective initially in most patients, some patients may not respond adequately or may develop recurrent symptoms, including diarrhea, despite therapy.

In clinical studies, telotristat ethyl reduced the frequency of daily bowel movements in patients with carcinoid syndrome diarrhea. Reductions in other symptoms of carcinoid syndrome (e.g., abdominal pain, flushing) not observed.