DiaBeta and Questran
Determining the interaction of DiaBeta and Questran and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using glyBURIDE together with cholestyramine can alter the effects of glyBURIDE, which can lead to loss of blood sugar control. Talk with your doctor before using glyBURIDE while you are using cholestyramine. GlyBURIDE should be administered at least one hour before or four to six hours after cholestyramine. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Cholestyramine may decrease hypoglycemic effect of some sulfonylureas by decreasing their absorption and enterohepatic recirculation. Data exist for glipizide; the effect of cholestyramine on the pharmacokinetics of other sulfonylureas is unknown.
MANAGEMENT: Sulfonylureas should be administered at least one hour before or four to six hours after cholestyramine. Patients receiving this combination should be advised to closely monitor their blood sugar and to notify their physician if loss of control occurs.
- Kivisto KT, Neuvonen PJ "The effect of cholestyramine and activated charcoal on glipizide absorption." Br J Clin Pharmacol 30 (1990): 733-6
- "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
Generic Name: glyburide
Brand name: DiaBeta, Glynase PresTab, Micronase, DiaBeta, Glynase
Synonyms: n.a.
Generic Name: cholestyramine
Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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