Diacomit and Premphase Prempro
Determining the interaction of Diacomit and Premphase Prempro and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Stiripentol may increase the blood levels and effects of medroxyPROGESTERone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant administration of stiripentol may significantly increase plasma concentrations, pharmacologic effects, and toxicities of drugs that are substrates of CYP450 2C19, 3A4, and/or 2D6. The mechanism is inhibition of cytochrome P-450 metabolism by stiripentol.
MANAGEMENT: Clinical and laboratory monitoring for altered efficacy and safety is recommended during concomitant use. Dosage adjustments may be required if increased plasma levels or effects are observed.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: conjugated estrogens / medroxyprogesterone
Brand name: Premphase, Prempro
Synonyms: Conjugated estrogens and medroxyprogesterone, Estrogens (Conjugated/Equine) and Medroxyprogesterone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diacomit-Prempro
- Diacomit-Prempro Low Dose
- Diacomit-Prempro Oral
- Diacomit-Premsyn PMS
- Diacomit-Prena1
- Diacomit-Prena1 True
- Premphase Prempro-Dialyvite
- Premphase Prempro-Dialyvite 3000
- Premphase Prempro-Dialyvite 5000
- Premphase Prempro-Dialyvite 800/Iron
- Premphase Prempro-Dialyvite Supreme D
- Premphase Prempro-Dialyvite Vitamin D 5000