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Diamox and Tegretol (Carbamazepine Tablets)

Determining the interaction of Diamox and Tegretol (Carbamazepine Tablets) and the possibility of their joint administration.

Check result:

Diamox <> Tegretol (Carbamazepine Tablets)

Relevance: 15.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

AcetaZOLAMIDE may increase the blood levels and effects of carBAMazepine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with a carbonic anhydrase inhibitor may increase the serum concentration and the risk of toxicity of carbamazepine. The mechanism of this interaction has not been delineated. In one report, three pediatric patients receiving the highest tolerable dose of carbamazepine without adverse effects experienced a 25% to 50% increase in their serum carbamazepine levels following the addition of acetazolamide 250 mg to 750 mg daily. In another report involving 54 pediatric patients with epilepsy, seizure control improved following the addition of acetazolamide 10 mg/kg daily and serum carbamazepine levels increased by 1 to 6 mg/L in 60% of 33 patients sampled. In those patients who developed carbamazepine toxicity, symptoms developed within 1 to 10 days of starting acetazolamide.

MANAGEMENT: Clinical monitoring of carbamazepine serum concentrations is recommended and the dosage should be adjusted accordingly. Patients should be advised to report possible signs of carbamazepine toxicity, such as headache, nausea, dizziness, slurred speech, nystagmus, visual disturbances, tremors, and ataxia, to their caregiver.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Tegretol (carbamazepine)." Novartis Pharmaceuticals, East Hanover, NJ.
Forsythe WI, Owens JR, Toothill C "Effectiveness of acetazolamide in the treatment of carbamazepine-resistant epilepsy in children." Dev Med Child Neurol 23 (1981): 761-9

Diamox

Generic Name: acetazolamide

Brand name: Diamox, Diamox Sequels

Synonyms: n.a.

What is Diamox?

Tegretol (Carbamazepine Tablets)

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Tegretol

What is Tegretol (Carbamazepine Tablets)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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