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Diamox Sequels and Edarbyclor

Determining the interaction of Diamox Sequels and Edarbyclor and the possibility of their joint administration.

Check result:

Diamox Sequels <> Edarbyclor

Relevance: 20.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In vitro data indicate that carbonic anhydrase inhibitors (CAIs) may significantly inhibit the binding or uptake of chlorthalidone in erythrocytes. Theoretically, this interaction could significantly increase the free, unbound fraction of chlorthalidone. The clinical consequences are not known, and more study is needed. The clinician should be aware that increased serum chlorthalidone levels and increased pharmacologic effect are possible during coadministration.

References

Beermann B, Hellstrom K, Lindstrom B, Rosen A "Binding-site interaction of chlorthalidone and acetazolamide, two drugs transported by red blood cells." Clin Pharmacol Ther 17 (1975): 424-32
Collste P, Holmstrom I "Effect of acetazolamide on the chlorthalidone level in the erythrocyte." In: Grahame-Smith, DG, ed. Drug interactions. Baltimore, Univ Park Press (1977): 287-91

Diamox Sequels

Generic Name: acetazolamide

Brand name: Diamox, Diamox Sequels

Synonyms: n.a.

What is Diamox Sequels?

Edarbyclor

Generic Name: azilsartan medoxomil / chlorthalidone

Brand name: Edarbyclor

Synonyms: n.a.

What is Edarbyclor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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