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Diarrest and Lincomycin Oral, Injection

Determining the interaction of Diarrest and Lincomycin Oral, Injection and the possibility of their joint administration.

Check result:

Diarrest <> Lincomycin Oral, Injection

Relevance: 01.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using lincomycin together with attapulgite. Using these medications together may cause lincomycin to be less effective. Contact your doctor immediately if your condition or infection worsens. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Adsorbent antidiarrheal agents may significantly reduce the gastrointestinal absorption of oral clindamycin and lincomycin, causing decreased serum levels and potential loss of antimicrobial effectiveness. Kaolin-pectin has been associated with a 90% reduction in lincomycin levels.

MANAGEMENT: The use of adsorbent antidiarrheals should be avoided if possible. If used concurrently, the patient should be monitored closely for loss of antibiotic efficacy.

References

McGehee RF Jr, Smith CB, Wilcox C, Finland M "Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin." Am J Med Sci 256 (1968): 279-92
"Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn, Kalamazoo, MI.
McCall CE, Steigbigel NH, Finland M "Lincomycin: activity in vitro and absorption and excretion in normal young men." Am J Med Sci 254 (1967): 144-55
"Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.
Albert KS, DeSante KA, Welch RD, DiSanto AR "Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin." J Pharm Sci 67 (1978): 1579-82

Diarrest

Generic Name: attapulgite

Brand name: Di-Gon II, Diarrest, Ka-Pec, Kao-Tin Advanced Formula

Synonyms: n.a.

What is Diarrest?

Lincomycin Oral, Injection

Generic Name: lincomycin

Brand name: Lincocin, Lincorex, L-Mycin, Bactramycin

Synonyms: Lincomycin

What is Lincomycin Oral, Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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