Diastat Pediatric and Spravato (84 MG Dose)
Determining the interaction of Diastat Pediatric and Spravato (84 MG Dose) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using esketamine together with diazePAM may increase side effects such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. After receiving treatment with esketamine, you should avoid driving or operating hazardous machinery until the next day after a restful sleep. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant use of esketamine with central nervous system (CNS) depressants may increase sedation and impairment of attention, judgment, thinking, reaction speed, and psychomotor skills. In clinical trials, 49% to 61% of esketamine-treated patients developed sedation based on the
Modified Observer's Alertness/Sedation scale (MOAA/s), and 0.3% of esketamine-treated patients experienced loss of consciousness (MOAA/s score of 0). In the MOAA/s scale, 5 means "responds readily to name spoken in normal tone" and 0 means "no response after painful trapezius squeeze," and any decrease in MOAA/s from pre-dosing of esketamine is considered to indicate presence of sedation. Dose-related increases in the incidence of sedation were observed in a fixed-dose study.
MANAGEMENT: Caution is advised and patients should be closely monitored during concomitant use of esketamine with CNS depressants. Due to the risk of delayed or prolonged sedation and other adverse effects, patients should be monitored for at least 2 hours after esketamine administration, followed by an assessment to determine when the patient is considered clinically stable and ready to leave the healthcare setting. Patients should be instructed not to engage in potentially hazardous activities, such as driving a motor vehicle or operating machinery, until the next day after a restful sleep.
- "Product Information. Spravato (esketamine)." Janssen Pharmaceuticals, Titusville, NJ.
Generic Name: diazepam
Brand name: Diastat AcuDial, Diastat Pediatric, Diastat, Valium, Diazepam Intensol, Zetran
Synonyms: n.a.
Generic Name: esketamine
Brand name: Spravato
Synonyms: Spravato Nasal Spray, Spravato
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Diastat Pediatric-Sprix Nasal Spray
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- Spravato (84 MG Dose)-Diatrizoate Injection
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- Spravato (84 MG Dose)-Diatrizoate Meglumine and Iodipamide Meglumine
- Spravato (84 MG Dose)-Diatx Zn
- Spravato (84 MG Dose)-Diazepam