Diazepam Intensol and Indinavir Sulfate
Determining the interaction of Diazepam Intensol and Indinavir Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Indinavir may increase the blood levels and effects of diazePAM. This can increase the risk of side effects including excessive drowsiness and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Indinavir may interfere with the metabolism of benzodiazepines. The mechanism is competitive inhibition of the CYP450 3A4 enzyme. The accumulation of benzodiazepines is associated with potentially serious and/or life-threatening events (e.g., prolonged sedation, respiratory depression).
MANAGEMENT: Patients receiving benzodiazepines should be monitored for excessive pharmacological effects such as sedation. Lorazepam, temazepam and oxazepam are metabolized by glucuronidation and are not expected to be affected by indinavir.
- "Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
- Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
Generic Name: diazepam
Brand name: Diazepam Intensol, Diastat, Diastat AcuDial, Diastat Pediatric, Valium, Zetran
Synonyms: n.a.
Generic Name: indinavir
Brand name: Crixivan
Synonyms: Indinavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diazepam Intensol-Indiomin MB
- Diazepam Intensol-Indium 111 Oxyquinoline
- Diazepam Intensol-Indium DTPA
- Diazepam Intensol-Indium In-111 Pentetreotide
- Diazepam Intensol-Indium Oxyquinoline
- Diazepam Intensol-Indocid
- Indinavir Sulfate-Diazepam Oral Concentrate
- Indinavir Sulfate-Diazepam Oral Solution
- Indinavir Sulfate-Diazepam Oral Solution Concentrate
- Indinavir Sulfate-Diazepam rectal
- Indinavir Sulfate-Diazepam Rectal Gel
- Indinavir Sulfate-Diazepam Solution