Diazepam Intensol and Marvelon 21
Determining the interaction of Diazepam Intensol and Marvelon 21 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral contraceptives may prolong the half-life of certain benzodiazepines that undergo hepatic oxidative metabolism (such as diazepam and chlordiazepoxide). Other benzodiazepines also may participate in this interaction. Close observation for signs and symptoms of altered benzodiazepine effect is recommended.
- Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP, Smith RB "Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics." Clin Pharmacol Ther 36 (1984): 683-90
- Abernethy DR, Greenblatt DJ, Divoll M, Arendt R, Ochs HR, Shader RI "Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids." N Engl J Med 306 (1982): 791-2
- Patwardhan RV, Mitchell MC, Johnson RF, Schenker S "Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines." Hepatology 3 (1983): 248-53
- Scavone JM, Greenblatt DJ, Locniskar A, Shader RI "Alprazolam pharmacokinetics in women on low-dose oral contraceptives." J Clin Pharmacol 28 (1988): 454-7
Generic Name: diazepam
Brand name: Diazepam Intensol, Diastat, Diastat AcuDial, Diastat Pediatric, Valium, Zetran
Synonyms: n.a.
Generic Name: desogestrel / ethinyl estradiol
Brand name: Azurette, Cyclessa, Desogen, Isibloom, Kariva, Mircette, Reclipsen, Cyred
Synonyms: Ethinyl estradiol and desogestrel, Ethinyl Estradiol and Desogestrel
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diazepam Intensol-Marvelon 28 - White Tablet
- Diazepam Intensol-Marvona SUIK
- Diazepam Intensol-Masanti Supreme
- Diazepam Intensol-Matulane
- Diazepam Intensol-Matzim LA
- Diazepam Intensol-Mavenclad
- Marvelon 21-Diazepam Oral Concentrate
- Marvelon 21-Diazepam Oral Solution
- Marvelon 21-Diazepam Oral Solution Concentrate
- Marvelon 21-Diazepam rectal
- Marvelon 21-Diazepam Rectal Gel
- Marvelon 21-Diazepam Solution