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Diazepam Intensol and Nexium I.V. Injection

Determining the interaction of Diazepam Intensol and Nexium I.V. Injection and the possibility of their joint administration.

Check result:

Diazepam Intensol <> Nexium I.V. Injection

Relevance: 11.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Esomeprazole may increase the blood levels and effects of diazePAM. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with esomeprazole may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of CYP450 2C19. The proposed mechanism is decreased clearance due to esomeprazole-mediated inhibition of CYP450 2C19. In a study involving epileptic patients, use of esomeprazole (40 mg) resulted in a 13% increase in trough plasma levels of phenytoin. Dose adjustments were not required in this study.

MANAGEMENT: Although a clinically significant interaction is unlikely, caution is advised if esomeprazole is used concomitantly with drugs that are substrates of CYP450 2C19. Clinical and laboratory monitoring may be appropriate whenever esomeprazole is added to or withdrawn from therapy with these drugs. Dosage adjustments may be considered if an interaction is suspected. Patients should be monitored for the development of adverse effects.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Nexium (esomeprazole)" Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Diazepam Intensol

Generic Name: diazepam

Brand name: Diazepam Intensol, Diastat, Diastat AcuDial, Diastat Pediatric, Valium, Zetran

Synonyms: n.a.

What is Diazepam Intensol?

Nexium I.V. Injection

Generic Name: esomeprazole

Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV

Synonyms: Esomeprazole

What is Nexium I.V. Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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