Diazepam Intensol and Sertraline

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

In a study consisting of 20 healthy male volunteers, pretreatment with sertraline (50 mg/day titrated to 200 mg/day over 10 days) for 22 days was associated with a 32% decrease in the systemic clearance of diazepam (10 mg single intravenous dose) relative to baseline, compared to a 19% decrease relative to baseline for the placebo group. There was no significant difference in the pharmacokinetics of N-demethyldiazepam, a major pharmacologically active metabolite of diazepam, before and after sertraline administration except for the time to reach peak plasma concentration (Tmax), which increased by 23% in the sertraline group and decreased by 19% in the placebo group. The clinical significance of these changes is unknown but should be minimal. However, caution is recommended during concomitant administration, as the risk of using sertraline with other CNS-active drugs has not been systematically evaluated.

Diazepam Intensol

Generic Name: diazepam

Brand name: Diazepam Intensol, Diastat, Diastat AcuDial, Diastat Pediatric, Valium, Zetran

Synonyms: n.a.

What is Diazepam Intensol?

Sertraline

Generic Name: sertraline

Brand name: Zoloft

Synonyms: n.a.

What is Sertraline?