Diazepam Intensol and Vemurafenib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Vemurafenib may increase the blood levels and effects of diazePAM. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with vemurafenib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of CYP450 2C8. The proposed mechanism, based on in vitro data, is decreased clearance due to vemurafenib-mediated inhibition of CYP450 2C8.

MANAGEMENT: Caution is advised if vemurafenib is used concomitantly with drugs that are substrates of CYP450 2C8, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever vemurafenib is added to or withdrawn from therapy with these drugs. Since vemurafenib has a long half-life, a wash-out period of 8 days following the discontinuation of vemurafenib has been suggested to avoid an interaction with subsequent therapy. Patients should be monitored for the development of adverse effects.

Diazepam Intensol

Generic Name: diazepam

Brand name: Diazepam Intensol, Diastat, Diastat AcuDial, Diastat Pediatric, Valium, Zetran

Synonyms: n.a.

What is Diazepam Intensol?

Vemurafenib

Generic Name: vemurafenib

Brand name: Zelboraf

Synonyms: n.a.

What is Vemurafenib?