Diazepam rectal and Medrol Dosepak
Determining the interaction of Diazepam rectal and Medrol Dosepak and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Certain corticosteroids may decrease the plasma concentration of some benzodiazepines. Limited data are available for midazolam and triazolam. The mechanism is related to induction of hepatic cytochrome P450 enzymes responsible for benzodiazepine metabolism. The clinical significance may depend on the dosage and duration of corticosteroid therapy and be of greater importance with oral administration of benzodiazepines.
- Villikka K, Kivisto KT, Neuvonen PJ "The effect of dexamethasone on the pharmacokinetics of triazolam." Pharmacol Toxicol 83 (1998): 135-8
- Nakajima M, Suzuki T, Sasaki T, Yokoi T, Hosoyamada A, Yamamoto T, Kuroiwa Y "Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans." Ther Drug Monit 21 (1999): 507-13
Generic Name: diazepam
Brand name: Valium, Diastat, Diastat AcuDial, Diastat Pediatric, Diazepam Intensol, Zetran
Synonyms: Diazepam
Generic Name: methylprednisolone
Brand name: Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack, A-methapred, Depo-Medrol, Solu-Medrol
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diazepam rectal-Medroloan II SUIK
- Diazepam rectal-Medroloan SUIK
- Diazepam rectal-Medrox (Capsaicin and Menthol Patch)
- Diazepam rectal-Medrox (Methyl Salicylate, Menthol, and Capsaicin Cream and Ointment)
- Diazepam rectal-Medrox (Methyl Salicylate, Menthol, and Capsaicin Patch)
- Diazepam rectal-Medrox-Rx
- Medrol Dosepak-Diazepam Rectal Gel
- Medrol Dosepak-Diazepam Solution
- Medrol Dosepak-Diazepam Tablet
- Medrol Dosepak-Diazepam Tablets
- Medrol Dosepak-Diazoxide
- Medrol Dosepak-Diazoxide Capsules