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Diazepam Tablet and Indinavir

Determining the interaction of Diazepam Tablet and Indinavir and the possibility of their joint administration.

Check result:

Diazepam Tablet <> Indinavir

Relevance: 11.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Indinavir may increase the blood levels and effects of diazePAM. This can increase the risk of side effects including excessive drowsiness and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Indinavir may interfere with the metabolism of benzodiazepines. The mechanism is competitive inhibition of the CYP450 3A4 enzyme. The accumulation of benzodiazepines is associated with potentially serious and/or life-threatening events (e.g., prolonged sedation, respiratory depression).

MANAGEMENT: Patients receiving benzodiazepines should be monitored for excessive pharmacological effects such as sedation. Lorazepam, temazepam and oxazepam are metabolized by glucuronidation and are not expected to be affected by indinavir.

References

"Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):

Diazepam Tablet

Generic Name: diazepam

Brand name: Valium, Diastat, Diastat AcuDial, Diastat Pediatric, Diazepam Intensol, Zetran

Synonyms: Diazepam

What is Diazepam Tablet?

Indinavir

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Indinavir?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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