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Diclofenac and misoprostol and MagGel

Determining the interaction of Diclofenac and misoprostol and MagGel and the possibility of their joint administration.

Check result:
Diclofenac and misoprostol <> MagGel
Relevance: 03.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using miSOPROStol together with magnesium oxide. Magnesium oxide or any magnesium-containing antacids can worsen miSOPROStol-induced diarrhea. Additionally, antacids in general can decrease the effects of miSOPROStol. If an antacid is needed, one that contains aluminum or calcium should be used. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid (the active metabolite of misoprostol), although clinical trials of misoprostol conducted with concomitant antacid use suggest that this effect is not clinically important.

MANAGEMENT: Use of misoprostol in combination with magnesium-containing antacids is not recommended. If an antacid is needed, one that contains aluminum or calcium should be prescribed.

References
  • Karim A, Rozek LF, Smith ME, Kowalski KG "Effects of food and antacid on oral absorption of misoprostol, a synthetic prostaglandin E1 analog." J Clin Pharmacol 29 (1989): 439-43
  • "Product Information. Arthrotec (diclofenac-misoprostol)." Searle, Skokie, IL.
Diclofenac and misoprostol

Generic Name: diclofenac / misoprostol

Brand name: Arthrotec

Synonyms: Diclofenac and Misoprostol

MagGel

Generic Name: magnesium oxide

Brand name: MagGel, Phillips' Cramp-free, Uro-Mag, Mag-200, Mag-Oxide, Magnesium Oxide 400, MAGnesium-Oxide, Maox, Uro-Mag, Mag-Ox 400, UroMag

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction