Diclofenac and misoprostol and Sodium Bicarbonate Infant Injection
Determining the interaction of Diclofenac and misoprostol and Sodium Bicarbonate Infant Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction is unknown. In twelve study subjects, coadministration of misoprostol with antacid reduced the bioavailability of misoprostol acid by 16% relative to fasting. Clinical trials of misoprostol conducted with concomitant antacid use suggest that this effect is not clinically important.
- Karim A, Rozek LF, Smith ME, Kowalski KG "Effects of food and antacid on oral absorption of misoprostol, a synthetic prostaglandin E1 analog." J Clin Pharmacol 29 (1989): 439-43
- "Product Information. Arthrotec (diclofenac-misoprostol)." Searle, Skokie, IL.
Generic Name: diclofenac / misoprostol
Brand name: Arthrotec
Synonyms: Diclofenac and Misoprostol
Generic Name: sodium bicarbonate
Brand name: Neut
Synonyms: Sodium bicarbonate, Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac and misoprostol-Sodium Bicarbonate Injection
- Diclofenac and misoprostol-Sodium bicarbonate Oral, Intravenous, Subcutaneous
- Diclofenac and misoprostol-Sodium Bicarbonate Tablets
- Diclofenac and misoprostol-Sodium Bicarbonate, Citric Acid, and Simethicone Effervescent Granule Pkt
- Diclofenac and misoprostol-Sodium biphosphate and sodium phosphate
- Diclofenac and misoprostol-Sodium biphosphate and sodium phosphate rectal
- Sodium Bicarbonate Infant Injection-Diclofenac and Misoprostol Delayed Release
- Sodium Bicarbonate Infant Injection-Diclofenac and Misoprostol Tablets
- Sodium Bicarbonate Infant Injection-Diclofenac Capsules
- Sodium Bicarbonate Infant Injection-Diclofenac Cream
- Sodium Bicarbonate Infant Injection-Diclofenac Delayed-Release Tablets
- Sodium Bicarbonate Infant Injection-Diclofenac epolamine