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Diclofenac and misoprostol and Tegretol

Determining the interaction of Diclofenac and misoprostol and Tegretol and the possibility of their joint administration.

Check result:

Diclofenac and misoprostol <> Tegretol

Relevance: 03.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

CarBAMazepine may reduce the blood levels of diclofenac, which may make the medication less effective in treating your condition. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with CYP450 2C9 inducers, such as rifampin, may decrease the plasma concentrations and therapeutic effects of diclofenac. The proposed mechanism is rifampin-mediated induction of CYP450 2C9, the isoenzyme responsible for the metabolic clearance of diclofenac. In a study involving 6 healthy subjects, after receiving rifampin 450 mg daily for 6 days, the Cmax and AUC of a single 100 mg dose of diclofenac was reduced by 43% and 67%, respectively.

MANAGEMENT: The potential for diminished pharmacologic effects of diclofenac should be considered during coadministration with CYP450 2C9 inducers, such as rifampin. Pharmacologic response to diclofenac should be monitored and the diclofenac dosage adjusted as necessary whenever a CYP450 2C9 inducer is added to or withdrawn from therapy.

References

"Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals, East Hanover, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0
Kumar JS, Rao Mamidi NVS, Chakrapani T "Rifampicin pretreatment reduces bioavailability of diclofenac sodium." Indian J Pharmacol 27 (1995): 183-5

Diclofenac and misoprostol

Generic Name: diclofenac / misoprostol

Brand name: Arthrotec

Synonyms: Diclofenac and Misoprostol

What is Diclofenac and misoprostol?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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