Diclofenac and Misoprostol Tablets and Sodium Bicarbonate Tablets
Determining the interaction of Diclofenac and Misoprostol Tablets and Sodium Bicarbonate Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction is unknown. In twelve study subjects, coadministration of misoprostol with antacid reduced the bioavailability of misoprostol acid by 16% relative to fasting. Clinical trials of misoprostol conducted with concomitant antacid use suggest that this effect is not clinically important.
- Karim A, Rozek LF, Smith ME, Kowalski KG "Effects of food and antacid on oral absorption of misoprostol, a synthetic prostaglandin E1 analog." J Clin Pharmacol 29 (1989): 439-43
- "Product Information. Arthrotec (diclofenac-misoprostol)." Searle, Skokie, IL.
Generic Name: diclofenac / misoprostol
Brand name: Arthrotec
Synonyms: Diclofenac and misoprostol, Diclofenac and Misoprostol
Generic Name: sodium bicarbonate
Brand name: Neut
Synonyms: Sodium bicarbonate, Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac and Misoprostol Tablets-Sodium Bicarbonate, Citric Acid, and Simethicone Effervescent Granule Pkt
- Diclofenac and Misoprostol Tablets-Sodium biphosphate and sodium phosphate
- Diclofenac and Misoprostol Tablets-Sodium biphosphate and sodium phosphate rectal
- Diclofenac and Misoprostol Tablets-Sodium cellulose phosphate
- Diclofenac and Misoprostol Tablets-Sodium chloride
- Diclofenac and Misoprostol Tablets-Sodium Chloride 0.45% Injection
- Sodium Bicarbonate Tablets-Diclofenac Capsules
- Sodium Bicarbonate Tablets-Diclofenac Cream
- Sodium Bicarbonate Tablets-Diclofenac Delayed-Release Tablets
- Sodium Bicarbonate Tablets-Diclofenac epolamine
- Sodium Bicarbonate Tablets-Diclofenac Epolamine Patch
- Sodium Bicarbonate Tablets-Diclofenac Extended Release Tablets 100mg