Diclofenac and Misoprostol Tablets and Verapamil Injection
Determining the interaction of Diclofenac and Misoprostol Tablets and Verapamil Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Diclofenac reduces serum verapamil concentrations. The mechanism is unknown. In a study involving 25 patients, the area under the verapamil plasma concentration-time curve was decreased 26% after one week and 29% after four weeks of concomitant diclofenac administration. The clinical significance of this interaction is unknown. However, patients on concomitant therapy should be monitored for reduced verapamil efficacy.
- Peterson MS, Basch C, Cohen A "Differential effects of naproxen and diclofenac on verapamil pharmacokinetics." Clin Pharmacol Ther 49 (1991): 129
Generic Name: diclofenac / misoprostol
Brand name: Arthrotec
Synonyms: Diclofenac and misoprostol, Diclofenac and Misoprostol
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac and Misoprostol Tablets-Verapamil Intravenous
- Diclofenac and Misoprostol Tablets-Verapamil Long-Acting Capsules
- Diclofenac and Misoprostol Tablets-Verapamil Long-Acting Tablets
- Diclofenac and Misoprostol Tablets-Verapamil oral/injection
- Diclofenac and Misoprostol Tablets-Verapamil Sustained-Release Capsules
- Diclofenac and Misoprostol Tablets-Verdeso
- Verapamil Injection-Diclofenac Capsules
- Verapamil Injection-Diclofenac Cream
- Verapamil Injection-Diclofenac Delayed-Release Tablets
- Verapamil Injection-Diclofenac epolamine
- Verapamil Injection-Diclofenac Epolamine Patch
- Verapamil Injection-Diclofenac Extended Release Tablets 100mg