Diclofenac Gel and Ibuprofen and Phenylephrine
Determining the interaction of Diclofenac Gel and Ibuprofen and Phenylephrine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using diclofenac topical together with ibuprofen. Both of these medications are considered nonsteroidal anti-inflammatory drugs. Since the medication in diclofenac topical may be absorbed from the skin, combining it with ibuprofen may increase the risk and/or severity of side effects reported with this class of drugs, including stomach ulcer, fluid retention, high blood pressure, bleeding, and liver or kidney problems. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs may be absorbed systemically following topical administration. Concomitant use with systemic nonsteroidal anti-inflammatory drugs may result in increased adverse effects such as gastrointestinal toxicity (inflammation, bleeding, ulceration, perforation), cardiovascular thrombotic events, hepatotoxicity (liver enzyme elevations), renal toxicity, fluid retention, edema, hypertension, and inhibition of platelet aggregation.
MANAGEMENT: Patients treated with topical preparations of nonsteroidal anti-inflammatory drugs should avoid or limit the use of systemic nonsteroidal anti-inflammatory drugs. Although systemic exposure is generally low following topical administration, absorption may be increased with frequent applications; use of large quantities or over large areas of skin; use on compromised or diseased skin or open wounds; and use of occlusive dressings or heating pads over application areas.
- "Product Information. Solaraze (diclofenac topical)." Doak Dermatologics Division, Fairfield, NJ.
Generic Name: diclofenac topical
Brand name: DST Plus Pak, Pennsaid, Solaraze, Voltaren Topical, Diclozor, Voltaren, Flector Patch, Klofensaid II, Vopac MDS, Xrylix, Flector, Licart
Synonyms: Diclofenac topical, Diclofenac (Topical)
Generic Name: ibuprofen / phenylephrine
Brand name: Advil Congestion Relief, Advil Sinus Congestion & Pain, Congestion Relief, Sudafed PE Head Congestion
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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