Diclofenac Oral Solution and Hydralazine and isosorbide dinitrate
Determining the interaction of Diclofenac Oral Solution and Hydralazine and isosorbide dinitrate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking hydrALAZINE, tell your doctor if you also use diclofenac. This combination may cause dizziness, headaches, or blurred vision. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of hydralazine and dihydralazine. This interaction suggests that prostaglandins play a pivotal role in the vasodilatory effects of hydralazine. However, data have been conflicting.
MANAGEMENT: Recommended management consists of monitoring the antihypertensive effectiveness of hydralazine or dihydralazine during therapy, increasing the dosage as necessary, or decreasing or substituting another drug for the NSAID.
- Cinquegrani MP, Liang CS "Indomethacin attenuates the hypotensive action of hydralazine." Clin Pharmacol Ther 39 (1986): 564-70
Generic Name: diclofenac
Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia
Synonyms: Diclofenac, Diclofenac (Systemic)
Generic Name: hydralazine / isosorbide dinitrate
Brand name: BiDil
Synonyms: Isosorbide Dinitrate and Hydralazine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac Oral Solution-Hydralazine Hydrochloride
- Diclofenac Oral Solution-Hydralazine Injection
- Diclofenac Oral Solution-Hydralazine Oral, Injection, Intravenous
- Diclofenac Oral Solution-Hydralazine Tablets
- Diclofenac Oral Solution-Hydrea
- Diclofenac Oral Solution-Hydrisalic Topical
- Hydralazine and isosorbide dinitrate-Diclofenac Potassium
- Hydralazine and isosorbide dinitrate-Diclofenac Powder Packets
- Hydralazine and isosorbide dinitrate-Diclofenac Sodium
- Hydralazine and isosorbide dinitrate-Diclofenac Sodium topical
- Hydralazine and isosorbide dinitrate-Diclofenac Sodium Topical Solution
- Hydralazine and isosorbide dinitrate-Diclofenac Tablets