Diclofenac Oral Solution and Isoptin SR
Determining the interaction of Diclofenac Oral Solution and Isoptin SR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Diclofenac reduces serum verapamil concentrations. The mechanism is unknown. In a study involving 25 patients, the area under the verapamil plasma concentration-time curve was decreased 26% after one week and 29% after four weeks of concomitant diclofenac administration. The clinical significance of this interaction is unknown. However, patients on concomitant therapy should be monitored for reduced verapamil efficacy.
- Peterson MS, Basch C, Cohen A "Differential effects of naproxen and diclofenac on verapamil pharmacokinetics." Clin Pharmacol Ther 49 (1991): 129
Generic Name: diclofenac
Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia
Synonyms: Diclofenac, Diclofenac (Systemic)
Generic Name: verapamil
Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac Oral Solution-Isopto Atropine
- Diclofenac Oral Solution-Isopto Atropine Ophthalmic
- Diclofenac Oral Solution-Isopto Atropine Ophthalmic Solution
- Diclofenac Oral Solution-Isopto Carbachol
- Diclofenac Oral Solution-Isopto Carbachol Ophthalmic Solution
- Diclofenac Oral Solution-Isopto Carpine
- Isoptin SR-Diclofenac Potassium
- Isoptin SR-Diclofenac Powder Packets
- Isoptin SR-Diclofenac Sodium
- Isoptin SR-Diclofenac Sodium topical
- Isoptin SR-Diclofenac Sodium Topical Solution
- Isoptin SR-Diclofenac Tablets