Diclofenac Potassium and Treprostinil Oral Inhalation Solution
Determining the interaction of Diclofenac Potassium and Treprostinil Oral Inhalation Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using treprostinil together with diclofenac can increase the risk of bleeding. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Prostacyclin/prostacyclin analogs (e.g., epoprostenol, iloprost, treprostinil) inhibit platelet aggregation and may theoretically potentiate the risk of bleeding in patients treated with other agents that affect hemostasis such as anticoagulants, platelet inhibitors, thrombin inhibitors, thrombolytic agents, or agents that commonly cause thrombocytopenia. In clinical trials for pulmonary hypertension, patients received concomitant anticoagulants and/or nonsteroidal anti-inflammatory agents without evidence of increased bleeding.
MANAGEMENT: Caution is advised if prostacyclin and prostacyclin analogs are used in combination with other drugs that affect hemostasis. Close clinical and laboratory observation for hemorrhagic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
- "Product Information. Ventavis (iloprost)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.
- "Product Information. Flolan (epoprostenol)." Glaxo Wellcome, Research Triangle Park, NC.
- "Product Information. Remodulin (treprostinil)." United Therapeutics Corp, Silver Spring, MD.
Generic Name: diclofenac
Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia
Synonyms: Diclofenac, Diclofenac (Systemic)
Generic Name: treprostinil
Brand name: Orenitram, Remodulin, Tyvaso, Tyvaso Refill Kit, Tyvaso Starter Kit
Synonyms: Treprostinil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac Potassium-Treprostinil Sodium
- Diclofenac Potassium-Tresiba
- Diclofenac Potassium-Tresiba FlexTouch
- Diclofenac Potassium-Tresiba FlexTouch (Insulin Degludec (U-100) Prefilled Pens)
- Diclofenac Potassium-Tresiba FlexTouch (Insulin Degludec (U-200) Prefilled Pens)
- Diclofenac Potassium-Tretin X
- Treprostinil Oral Inhalation Solution-Diclofenac Powder Packets
- Treprostinil Oral Inhalation Solution-Diclofenac Sodium
- Treprostinil Oral Inhalation Solution-Diclofenac Sodium topical
- Treprostinil Oral Inhalation Solution-Diclofenac Sodium Topical Solution
- Treprostinil Oral Inhalation Solution-Diclofenac Tablets
- Treprostinil Oral Inhalation Solution-Diclofenac topical