Diclofenac Powder Packets and Pentazocine Acetaminophen
Determining the interaction of Diclofenac Powder Packets and Pentazocine Acetaminophen and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using pentazocine together with diclofenac may cause seizures. Contact your doctor if you experience tremors, involuntary muscle movements, and seizures. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Grand mal seizures following a single diclofenac dose have been reported in a patient on long-term pentazocine therapy. Seizures recurred upon inadvertent rechallenge with diclofenac. The role pentazocine played in this case remains to be determined. However, pentazocine is known to reduce the seizure threshold.
MANAGEMENT: Patients receiving this combination should be monitored for increased CNS stimulation (tremors, involuntary muscle movements, seizures) and should be advised to notify their physician if they experience such symptoms.
- Heim M, Nadvorna H, Azaria M "Grand mal seizures following treatment with diclofenac and pentazocine." S Afr Med J 78 (1990): 700-1
Generic Name: diclofenac
Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia
Synonyms: Diclofenac, Diclofenac (Systemic)
Generic Name: acetaminophen / pentazocine
Brand name:
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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