Diclofenac Sodium and Oxaprozin Potassium
Determining the interaction of Diclofenac Sodium and Oxaprozin Potassium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Concomitant use of more than one nonsteroidal anti-inflammatory drug (NSAID) at a time may increase the potential for serious gastrointestinal toxicity including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, or intestines. These events can occur at any time during NSAID use, with or without warning symptoms. The risk is dependent on both dosage and duration of therapy. Patients with a prior history of peptic ulcer disease and/or GI bleeding have a greater than 10-fold increased risk of developing a GI bleed during NSAID use compared to patients without a history. Additional risk factors include old age, alcohol use, smoking, and poor general health status. MANAGEMENT: Concomitant use of more than one NSAID at a time should generally be avoided. Patients treated with an NSAID should be advised to take it with food and to immediately report signs and symptoms of GI ulceration and bleeding such as severe abdominal pain, dizziness, lightheadedness, and the appearance of black, tarry stools. The selective use of prophylactic anti-ulcer therapy (e.g., antacids, misoprostol, proton pump inhibitors) may be considered in high risk patients. References "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT. "Product Information. Duexis (famotidine-ibuprofen)." Horizon Pharma USA Inc, Northbrook, IL. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA. "Product Information. VIMOVO (esomeprazole-naproxen)." Astra-Zeneca Pharmaceuticals, Wilmington, DE. "Product Information. Etodolac ER (etodolac)." Taro Pharmaceuticals U.S.A. Inc, Hawthorne, NY. "Product Information. Cambia (diclofenac)." Kowa Pharmaceuticals America (formerly ProEthic), Montgomery, AL. "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc, Morgantown, WV. "Product Information. Ketoprofen ER (ketoprofen)." Mylan Pharmaceuticals Inc, Morgantown, WV. "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL. "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA. "Product Information. Ponstel (mefenamic acid)." Pfizer U.S. Pharmaceuticals Group, New York, NY. "Product Information. Anaprox (naproxen)." Roche Laboratories, Nutley, NJ. "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS. "Product Information. Caldolor (ibuprofen)." Cumberland Pharmaceuticals Inc, Nashville, TN. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA. View all 15 references
Professional:GENERALLY AVOID: Concomitant use of more than one nonsteroidal anti-inflammatory drug (NSAID) at a time may increase the potential for serious gastrointestinal toxicity including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, or intestines. These events can occur at any time during NSAID use, with or without warning symptoms. The risk is dependent on both dosage and duration of therapy. Patients with a prior history of peptic ulcer disease and/or GI bleeding have a greater than 10-fold increased risk of developing a GI bleed during NSAID use compared to patients without a history. Additional risk factors include old age, alcohol use, smoking, and poor general health status.
MANAGEMENT: Concomitant use of more than one NSAID at a time should generally be avoided. Patients treated with an NSAID should be advised to take it with food and to immediately report signs and symptoms of GI ulceration and bleeding such as severe abdominal pain, dizziness, lightheadedness, and the appearance of black, tarry stools. The selective use of prophylactic anti-ulcer therapy (e.g., antacids, misoprostol, proton pump inhibitors) may be considered in high risk patients.
- "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.
- "Product Information. Duexis (famotidine-ibuprofen)." Horizon Pharma USA Inc, Northbrook, IL.
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
- "Product Information. VIMOVO (esomeprazole-naproxen)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
- "Product Information. Etodolac ER (etodolac)." Taro Pharmaceuticals U.S.A. Inc, Hawthorne, NY.
- "Product Information. Cambia (diclofenac)." Kowa Pharmaceuticals America (formerly ProEthic), Montgomery, AL.
- "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc, Morgantown, WV.
- "Product Information. Ketoprofen ER (ketoprofen)." Mylan Pharmaceuticals Inc, Morgantown, WV.
- "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
- "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA.
- "Product Information. Ponstel (mefenamic acid)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
- "Product Information. Anaprox (naproxen)." Roche Laboratories, Nutley, NJ.
- "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS.
- "Product Information. Caldolor (ibuprofen)." Cumberland Pharmaceuticals Inc, Nashville, TN.
- "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Generic Name: diclofenac
Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia
Synonyms: Diclofenac, Diclofenac (Systemic)
Generic Name: oxaprozin
Brand name: Daypro
Synonyms: Oxaprozin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac Sodium-Oxaprozin Tablets
- Diclofenac Sodium-Oxaydo
- Diclofenac Sodium-Oxazepam
- Diclofenac Sodium-Oxcarbazepine
- Diclofenac Sodium-Oxcarbazepine Extended-Release Tablets
- Diclofenac Sodium-Oxcarbazepine Oral Suspension
- Oxaprozin Potassium-Diclofenac Sodium topical
- Oxaprozin Potassium-Diclofenac Sodium Topical Solution
- Oxaprozin Potassium-Diclofenac Tablets
- Oxaprozin Potassium-Diclofenac topical
- Oxaprozin Potassium-Diclofenac Topical Patch
- Oxaprozin Potassium-Diclofenac Topical Solution