Diclofenac (Systemic) and Verelan PM
Determining the interaction of Diclofenac (Systemic) and Verelan PM and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Diclofenac reduces serum verapamil concentrations. The mechanism is unknown. In a study involving 25 patients, the area under the verapamil plasma concentration-time curve was decreased 26% after one week and 29% after four weeks of concomitant diclofenac administration. The clinical significance of this interaction is unknown. However, patients on concomitant therapy should be monitored for reduced verapamil efficacy.
- Peterson MS, Basch C, Cohen A "Differential effects of naproxen and diclofenac on verapamil pharmacokinetics." Clin Pharmacol Ther 49 (1991): 129
Generic Name: diclofenac
Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia
Synonyms: Diclofenac
Generic Name: verapamil
Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac (Systemic)-Veripred 20
- Diclofenac (Systemic)-Vermox
- Diclofenac (Systemic)-Versacloz
- Diclofenac (Systemic)-Versed
- Diclofenac (Systemic)-Versed injection
- Diclofenac (Systemic)-Versiclear
- Verelan PM-Diclofenac and misoprostol
- Verelan PM-Diclofenac and Misoprostol Delayed Release
- Verelan PM-Diclofenac and Misoprostol Tablets
- Verelan PM-Diclofenac Capsules
- Verelan PM-Diclofenac Cream
- Verelan PM-Diclofenac Delayed-Release Tablets