Diclofenac Tablets and Lamivudine and zidovudine
Determining the interaction of Diclofenac Tablets and Lamivudine and zidovudine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using zidovudine together with diclofenac may increase the risk of bleeding in HIV-positive patients with hemophilia. However, the interaction is not fully understood, and evidence is limited. Talk to your doctor or pharmacist if you have any concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited clinical data suggest that the concomitant use of zidovudine with nonsteroidal anti-inflammatory agents may increase the risk of hematological toxicity and/or bleeding in HIV-positive patients with hemophilia. The mechanism is unknown.
MANAGEMENT: It is recommended to monitor patients for side effects and bleeding during concomitant use.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21
- Sahai J, Gallicano K, Conway B, et al. "Lack of pharmacokinetic interaction between naproxen (N) and zidovudine (Z)." Clin Pharmacol Ther 51 (1992): 184
- Sahai J, Gallicano K, Garber G, et al. "Evaluation of the in vivo effect of naproxen on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus." Clin Pharmacol Ther 52 (1992): 464-70
- Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
Generic Name: diclofenac
Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia
Synonyms: Diclofenac, Diclofenac (Systemic)
Generic Name: lamivudine / zidovudine
Brand name: Combivir
Synonyms: Lamivudine and Zidovudine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diclofenac Tablets-Lamivudine and Zidovudine Tablets
- Diclofenac Tablets-Lamivudine Oral Solution
- Diclofenac Tablets-Lamivudine Tablets
- Diclofenac Tablets-Lamotrigine
- Diclofenac Tablets-Lamotrigine Chewable Dispersible Tablets
- Diclofenac Tablets-Lamotrigine Chewable Tablet
- Lamivudine and zidovudine-Diclofenac topical
- Lamivudine and zidovudine-Diclofenac Topical Patch
- Lamivudine and zidovudine-Diclofenac Topical Solution
- Lamivudine and zidovudine-Diclofenac transdermal
- Lamivudine and zidovudine-Diclofex DC
- Lamivudine and zidovudine-Diclosiacin