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Didanosine and Retrovir

Determining the interaction of Didanosine and Retrovir and the possibility of their joint administration.

Check result:

Didanosine <> Retrovir

Relevance: 23.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In one study, concomitant use of zidovudine and didanosine increased zidovudine elimination half-life by 18% and increased the area under the plasma concentration-time curve by 35%. However, several other studies (including one pediatric study) failed to demonstrate significant pharmacokinetic alterations of either drug when zidovudine and didanosine were administered concurrently. A consistent pharmacokinetic interaction does not appear to exist between these two drugs, but it may be appropriate to monitor for increased toxicities during simultaneous therapy.

References

Knupp CA, Milbrath R, Barbhaiya RH "Effect of time of food administration on the bioavailbility of didanosine from a chewable tablet formulation." J Clin Pharmacol 33 (1993): 568-73
Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21

Didanosine

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: n.a.

What is Didanosine?

Retrovir

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection)

What is Retrovir?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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