Didanosine Delayed-Release Enteric-Coated Capsules and Evotaz

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using didanosine together with atazanavir may decrease the effects of atazanavir. Atazanavir should be administered, with food, 2 hours before or 1 hour after didanosine. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concurrent administration of didanosine buffered tablets or powder or the pediatric oral solution may significantly decrease the oral bioavailability of atazanavir. Atazanavir solubility decreases with increasing pH, thus buffering agents in the didanosine formulations may interfere with dissolution of the drug. In 32 study subjects, simultaneous administration of didanosine buffered tablets (200 mg single dose) and stavudine (40 mg single dose) reduced the plasma concentrations of atazanavir (400 mg single dose) by over 80% compared to administration of atazanavir alone. The interaction was not observed when atazanavir was administered one hour after didanosine and stavudine. Atazanavir also had no significant effects on the pharmacokinetics of didanosine or stavudine during concurrent administration.

MANAGEMENT: Atazanavir should be administered, with food, 2 hours before or 1 hour after didanosine buffered formulations. Didanosine delayed-release capsules are not buffered and are not expected to cause this interaction. However, because didanosine should be administered on an empty stomach, the capsules should also be administered at different times from atazanavir.

Didanosine Delayed-Release Enteric-Coated Capsules

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: Didanosine

What is Didanosine Delayed-Release Enteric-Coated Capsules?

Evotaz

Generic Name: atazanavir / cobicistat

Brand name: Evotaz

Synonyms: n.a.

What is Evotaz?