Didanosine Delayed-Release Enteric-Coated Capsules and Ketoconazole (Systemic)
Determining the interaction of Didanosine Delayed-Release Enteric-Coated Capsules and Ketoconazole (Systemic) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using didanosine together with ketoconazole may decrease the effects of ketoconazole. Separation of doses by two hours is recommended. It may be preferable to administer ketoconazole first. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: The buffer system of didanosine may reduce absorption of ketoconazole by increasing gastric pH.
MANAGEMENT: Separation of doses by two hours is recommended. It may be preferable to give the ketoconazole dose first. Fluconazole does not appear to interact with didanosine. Patients should be monitored for altered antifungal effects.
- Moreno F, Hardin TC, Rimaldi MG, Graybill JR "Itraconazole-didanosine excipient interaction." JAMA 269 (1993): 1508
- May DB, Drew RH, Yedinak KC, Bartlett JA "Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers." Pharmacotherapy 14 (1994): 509-13
Generic Name: didanosine
Brand name: Videx, Videx EC
Synonyms: Didanosine
Generic Name: ketoconazole
Brand name: Nizoral
Synonyms: Ketoconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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