Didanosine Tablet, for suspension and Methadone Injection Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

The pediatric powder formulation of didanosine should not be used with methadone. Combining these medications can significantly reduce the blood levels of didanosine and possibly make it ineffective. Other formulations of didanosine may be used with methadone. However, you may need more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with methadone may significantly decrease the plasma concentrations of didanosine from the pediatric powder formulation. The mechanism of interaction has not been described. In 16 study subjects receiving methadone chronic maintenance, didanosine peak plasma concentration (Cmax) and systemic exposure (AUC) following a single 200 mg dose were 66% and 57% lower, respectively, compared to a parallel control group not receiving methadone. When a 400 mg dose of enteric-coated, delayed-release formulation of didanosine was given to methadone patients, didanosine Cmax and AUC decreased by 16% and 17%, respectively, compared to historical control values reported in healthy subjects.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, didanosine pediatric powder should not be prescribed in combination with methadone. If coadministration of didanosine and methadone is necessary, the recommended formulation of didanosine is the enteric-coated, delayed-release formulation (Videx EC). Patients should be closely monitored for adequate clinical response when Videx EC is coadministered with methadone, including monitoring for changes in HIV RNA viral load.

Didanosine Tablet, for suspension

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: Didanosine

What is Didanosine Tablet, for suspension?

Methadone Injection Solution

Generic Name: methadone

Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets

Synonyms: Methadone

What is Methadone Injection Solution?