Didanosine Tablet, for suspension and Sporanox Capsules
Determining the interaction of Didanosine Tablet, for suspension and Sporanox Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using didanosine together with itraconazole may decrease the effects of itraconazole. Separation of doses by two hours is recommended. It may be preferable to administer itraconazole first. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: The buffer system of didanosine may reduce absorption of itraconazole by increasing gastric pH. Treatment failure may result.
MANAGEMENT: Separation of doses by two hours is recommended. It may be preferable to administer itraconazole first. Fluconazole does not appear to interact with didanosine.
- May DB, Drew RH, Yedinak KC, Bartlett JA "Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers." Pharmacotherapy 14 (1994): 509-13
- Moreno F, Hardin TC, Rimaldi MG, Graybill JR "Itraconazole-didanosine excipient interaction." JAMA 269 (1993): 1508
Generic Name: didanosine
Brand name: Videx, Videx EC
Synonyms: Didanosine
Generic Name: itraconazole
Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura
Synonyms: Itraconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Didanosine Tablet, for suspension-Spravato (56 MG Dose)
- Didanosine Tablet, for suspension-Spravato (84 MG Dose)
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- Sporanox Capsules-Diethylpropion
- Sporanox Capsules-Diethylpropion Controlled-Release Tablets