Diflucan (Fluconazole Injection Solution) and Retrovir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using zidovudine together with fluconazole may increase the effects of zidovudine. Contact your doctor if you experience unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, nausea, vomiting, stomach pain, and numbness or cold feeling in your arms or legs, diarrhea, loss of appetite, stomach pain, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Fluconazole may significantly reduce zidovudine clearance, and increase its elimination half-life and AUC. The mechanism is unknown but may be related to inhibition of its hepatic metabolism.

MANAGEMENT: Patients receiving concomitant fluconazole and zidovudine should be monitored for clinical and laboratory evidence of zidovudine toxicity such as anemia, neutropenia, abnormal liver function tests, myopathy, or lactic acidosis. Zidovudine dose reductions or discontinuation of fluconazole may be necessary.

Diflucan (Fluconazole Injection Solution)

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Diflucan

What is Diflucan (Fluconazole Injection Solution)?

Retrovir

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection)

What is Retrovir?