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Diflucan Intravenous and Theo-Dur

Determining the interaction of Diflucan Intravenous and Theo-Dur and the possibility of their joint administration.

Check result:

Diflucan Intravenous <> Theo-Dur

Relevance: 05.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Fluconazole may increase the blood levels and effects of theophylline. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, heart palpitations, and/or irregular heartbeat, as these may be signs and symptoms of excessive theophylline levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The concurrent use of fluconazole may increase the serum concentrations of theophylline in some patients. The mechanism is unknown. When fluconazole 200 mg/day for 14 days was coadministered, the plasma clearance of theophylline decreased by an average of 18%. Toxicity could occur in patients whose theophylline levels are at the upper end of the therapeutic range.

MANAGEMENT: Clinical and laboratory monitoring is warranted if these agents are given concurrently. Dose adjustments are recommended if an interaction is suspected. Patients receiving this combination should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their doctor.

References

Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
"Product Information. Diflucan (fluconazole)." Roerig Division, New York, NY.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Tett S, Carey D, Lee H-S "Drug interactions with fluconazole." Med J Aust 156 (1992): 365
Konishi H, Morita K, Yamaji A "Effect of fluconazole on theophylline disposition in humans." Eur J Clin Pharmacol 46 (1994): 309-12

Diflucan Intravenous

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Diflucan

What is Diflucan Intravenous?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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