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Diflucan Intravenous and Zorvolex

Determining the interaction of Diflucan Intravenous and Zorvolex and the possibility of their joint administration.

Check result:

Diflucan Intravenous <> Zorvolex

Relevance: 05.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Fluconazole may increase the blood levels and effects of diclofenac. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inhibitors of CYP450 2C9 may increase the plasma concentrations of diclofenac, which is primarily metabolized by the isoenzyme. When the last dose of CYP450 2C9 inhibitor voriconazole (400 mg every 12 hours on day 1, followed by 200 mg every 12 hours on day 2) was coadministered with a single dose of diclofenac (50 mg), the peak plasma concentration (Cmax) and systemic exposure (AUC) of diclofenac increased by 114% and 78%, respectively, compared to diclofenac alone.

MANAGEMENT: Caution is advised if diclofenac is prescribed in combination with an inhibitor of CYP450 2C9. Some authorities recommend a reduction of the maximum diclofenac dose to 100 mg per day when coadministered with a CYP450 2C9 inhibitor.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Arthrotec (diclofenac-misoprostol)." Searle, Skokie, IL.

Diflucan Intravenous

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Diflucan

What is Diflucan Intravenous?

Zorvolex

Generic Name: diclofenac

Brand name: Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex, Voltaren, Dyloject, also Cambia

Synonyms: n.a.

What is Zorvolex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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