Diflucan IV and Macrobid

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using fluconazole together with nitrofurantoin may increase the risk of liver and lung toxicity. This may be more likely to occur in older adults or those with a debilitating condition. Talk with your doctor before using these medications together. Call the doctor if you have side effects such as cough, shortness of breath, fatigue, or pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant administration of nitrofurantoin and fluconazole may increase the risk of hepatic and pulmonary toxicity. The mechanism is unknown. A 73-year-old patient who had been taking nitrofurantoin for 5 years developed respiratory symptoms (fatigue, dyspnea, cough, pleuritic pain, and tracheal pain) and hepatic enzyme elevations 2 months after fluconazole 150 mg/week was added to his regimen. A diagnosis of pulmonary fibrosis was made after chest X-rays and respiratory tests were performed. The patient also took multiple other drugs including terazosin, cimetidine, fluticasone nasal spray, diphenhydramine, ibuprofen, fluocinonide ointment, multivitamin, vitamin E, calcium-vitamin D, aspirin, calcium polycarbophil, and docusate, and drank moderate amounts of alcohol. Symptoms improved gradually after discontinuation of nitrofurantoin and fluconazole. Nitrofurantoin alone is known to cause pulmonary toxicity (usually pulmonary fibrosis or interstitial pneumonitis) and both drugs individually have been associated with hepatic toxicity.

MANAGEMENT: Until more information is available it may be advisable to monitor patients for signs of adverse pulmonary and hepatic effects during concomitant administration. Patients should be advised to notify their physician if they develop cough, dyspnea, fatigue, or pain.

Diflucan IV

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Diflucan

What is Diflucan IV?

Macrobid

Generic Name: nitrofurantoin

Brand name: Furadantin, Macrobid, Macrodantin, Nitro Macro

Synonyms: n.a.

What is Macrobid?