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Diflucan IV and Mycobutin

Determining the interaction of Diflucan IV and Mycobutin and the possibility of their joint administration.

Check result:

Diflucan IV <> Mycobutin

Relevance: 06.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifabutin together with fluconazole may increase the effects of rifabutin. Contact your doctor if you experience pale skin, weakness, easy bruising or bleeding, fever, chills, body aches, flu symptoms, headache, nausea, vomiting, or stomach pain. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant administration of fluconazole has been shown to increase the maximum serum concentration of rifabutin and to decrease rifabutin clearance. The mechanism is inhibition of CYP450 3A4 hepatic microsomal enzymes. Additionally, rifabutin may increase the metabolism of fluconazole due to induction of CYP450 metabolism. Subtherapeutic levels of the azole may result.

MANAGEMENT: Patients who receive this combination should be monitored for rifabutin toxicity (e.g., neutropenia, uveitis). Antimicrobial activity should be monitored, and dosages should be adjusted as needed.

References

Jordan MK, Polis MA, Kelly G, Narang PK, Masur H, Piscitelli SC "Effects of fluconazole and clarithromycin on rifabutin and 25-O-desacetylrifabutin pharmacokinetics." Antimicrob Agents Chemother 44 (2000): 2170-72
Trapnell CB, Narang PK, Li R, Lavelle JP "Increased plasma rifabutin levels with concomitant fluconazole therapy in HIV-infected patients." Ann Intern Med 124 (1996): 573-6

Diflucan IV

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Diflucan

What is Diflucan IV?

Mycobutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Mycobutin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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