Diflunisal and Loestrin 24 Fe
Determining the interaction of Diflunisal and Loestrin 24 Fe and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral contraceptives may enhance the clearance of diflunisal. In one study, plasma clearance of diflunisal was significantly increased in women on oral contraceptives, averaging 0.165 mL/min/kg. In women not taking oral contraceptives, plasma clearance of diflunisal averaged 0.108 mL/min/kg. The clinical significance of this interaction is unknown.
- Macdonald JI, Herman RJ, Verbeeck RK "Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal." Eur J Clin Pharmacol 38 (1990): 175-9
Generic Name: ethinyl estradiol / norethindrone
Brand name: Loestrin 24 Fe, Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diflunisal-Loestrin Fe 1.5/30
- Diflunisal-Loestrin Fe 1/20
- Diflunisal-Lofexidine
- Diflunisal-Lofexidine Hydrochloride
- Diflunisal-Lofibra
- Diflunisal-Lofibra Capsules
- Loestrin 24 Fe-Difluprednate
- Loestrin 24 Fe-Difluprednate ophthalmic
- Loestrin 24 Fe-Digex NF
- Loestrin 24 Fe-Digibind
- Loestrin 24 Fe-DigiFab
- Loestrin 24 Fe-Digitaline Nativelle