Drug search by name

Diflunisal and Probenecid and colchicine

Determining the interaction of Diflunisal and Probenecid and colchicine and the possibility of their joint administration.

Check result:

Diflunisal <> Probenecid and colchicine

Relevance: 02.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may increase the pharmacologic and toxic effects of diflunisal in some patients by inhibition of hepatic metabolism and displacement from plasma protein-binding sites. Increased diflunisal concentrations may result. The clinical significance has not been reported. When these drugs are combined, patients should be observed for diflunisal toxicity such as nausea, vomiting, drowsiness, tinnitus, tachycardia, sweating, or confusion.

References

Diamond JS, Paolino JS "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest 52 (1973): 1491-9
Macdonald JI, Wallace SM, Herman RJ, Verbeeck RK "Effect of propenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal." Eur J Clin Pharmacol 47 (1995): 519-23
Regal RE "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm 21 (1987): 219-20

Diflunisal

Generic Name: diflunisal

Brand name: Dolobid

Synonyms: n.a.

What is Diflunisal?

Probenecid and colchicine

Generic Name: colchicine / probenecid

Brand name:

Synonyms: Probenecid and colchicine (Oral)

What is Probenecid and colchicine?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions