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Diflunisal and Zovia 1/35

Determining the interaction of Diflunisal and Zovia 1/35 and the possibility of their joint administration.

Check result:

Diflunisal <> Zovia 1/35

Relevance: 02.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Oral contraceptives may enhance the clearance of diflunisal. In one study, plasma clearance of diflunisal was significantly increased in women on oral contraceptives, averaging 0.165 mL/min/kg. In women not taking oral contraceptives, plasma clearance of diflunisal averaged 0.108 mL/min/kg. The clinical significance of this interaction is unknown.

References

Macdonald JI, Herman RJ, Verbeeck RK "Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal." Eur J Clin Pharmacol 38 (1990): 175-9

Diflunisal

Generic Name: diflunisal

Brand name: Dolobid

Synonyms: n.a.

What is Diflunisal?

Zovia 1/35

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/35E

What is Zovia 1/35?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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